Welding PROxAb Shuttles: A modular approach for generating bispecific antibodies via site-specific protein-protein conjugation
Tanja Lehmann, Hendrik Schneider, Jason Tonillo, Jennifer Schanz, Daniel F. Schwarz, Christian J. Schröter, Sebastian Jäger, Harald Kolmar, Stefan Hecht, Jan Anderl, Nicolas Rasche, Marcel Rieker, Stephan Dickgießer
The paper describes a modular method to generate PROxAb Shuttles by conjugating PROTAC-binding VHHs to antibodies, enabling targeted protein degradation and bispecific antibody creation.
Bioconjugate Chemistry · May 29, 2024Peer-reviewedBiochemistry