Christian J. Schröter

HM-DyadCap - Capture and Mapping of 5-Hydroxymethylcytosine/5-Methylcytosine CpG Dyads in Mammalian DNA

HM-DyadCap captures and maps hmC/mC CpG dyads in mammalian DNA, revealing their enrichment in gene bodies and depletion at transcription start sites.

Comparative human embryo-mapping reveals neural bias of neuromesodermal progenitors in stem cell axial elongation models

The paper maps scRNA-seq from stem cell-based axial organoids to a human embryo, revealing three origins of axial development and the neural bias of neuromesodermal progenitors.

Single-cell multiome uncovers differences in glycogen metabolism underlying species-specific speed of development

The paper identifies glycogen metabolism differences in pluripotent cells across species that influence neural differentiation speed.

Tissue-intrinsic Wnt signals antagonize Nodal-driven AVE differentiation

The paper shows that Wnt signaling within the visceral endoderm restricts AVE differentiation, independent of BMP gradients, using mouse stem cell aggregates.

Welding PROxAb Shuttles: A modular approach for generating bispecific antibodies via site-specific protein-protein conjugation

The paper describes a modular method to generate PROxAb Shuttles by conjugating PROTAC-binding VHHs to antibodies, enabling targeted protein degradation and bispecific antibody creation.

Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States

The paper captures two human axial stem cell states and identifies regulatory networks and mechanisms underlying their maintenance and differentiation.

Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells

The paper investigates how FGF and BMP signaling interact to guide mesoderm differentiation in stem cells, finding that FGF promotes its own signaling while suppressing BMP, leading to distinct cell lineages.

Intermittent ERK oscillations downstream of FGF in mouse embryonic stem cells

The paper measures ERK activity dynamics in mouse embryonic stem cells in response to FGF4 and finds oscillations that vary with FGF4 dose and cell state.

Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells

The paper shows that FGF4-mediated cell-cell communication ensures stable proportions of differentiated cell types in mouse embryonic stem cells despite initial variability and perturbations.

Robustness and timing of cellular differentiation through population-based symmetry breaking

This paper proposes a population-based dynamical framework for cellular differentiation that explains robustness and timing through symmetry breaking in growing cell populations.