Vascularized Human Cardiac Organoids Reveal Endothelial-Cardiomyocyte Crosstalk and Mechanisms of Carfilzomib-Induced Cardiotoxicity
Yuan Yang, Liyang Zhao, Honglin Tao, Yao Zhang, Hanwen Wang, Henghui Xu, Ning Ma, Ning‐Yi Shao, Joe Z. Zhang
This study creates vascularized human cardiac organoids to study endothelial-cardiomyocyte interactions and cardiotoxicity mechanisms, finding bidirectional crosstalk and ER stress pathways involved in drug toxicity.
bioRxiv · Apr 16, 2026 · PreprintCell Biology