Ning‐Yi Shao

The paper introduces mpTCRai, a deep learning framework that maps structural perturbations to energetic changes in TCRs, enabling precise and safe TCR design for immunotherapy.

This study creates vascularized human cardiac organoids to study endothelial-cardiomyocyte interactions and cardiotoxicity mechanisms, finding bidirectional crosstalk and ER stress pathways involved in drug toxicity.

This study uses machine learning to identify Treg-mediated mechanisms by which nMSCs and their secretome improve diastolic function in HFpEF.

This paper identifies GSDME as a mediator of neurodegeneration in Parkinson's disease by linking mitochondrial damage to pyroptotic cell death through caspase-3 activation.