PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain
Eduardo Gutierrez Kuri, Juliet Lynn Marie Garcia-Rogers, Jaid Perez, Sabrina Smith, Matthew R. Kenwood, Kahealani S. Archuleta, Yangming Xiao, Gabriela Campos, Savannah Barannikov, Hu Wang, Sammy Pardo, Trevor B. Romsdahl, Henry Miller, Ann Marie Stowe, Russell William, , Juan Pablo Palavicini
This study investigates the effects of PLCγ2 deficiency in mice, showing impaired immune tolerance, myelin homeostasis disruption, and enhanced oxidative metabolism in the brain.
bioRxiv · Jul 14, 2026 · PreprintNeuroscience