A VSV-vector vaccine simultaneously targeting H5N1 hemagglutinin (HA) and matrix protein 2 (M2) induces robust neutralizing and ADCC antibody responses and provides full protection against lethal H5N1 infection in a mouse model
Zhujun Ao, Robert Vendramelli, Maryann Buyu, Thăng Trương, D Liu, Nick Gao, Heqing Ma, Stephen Amos, Peter Lawrynuik, Maurice Nyamekye, Keith Raymond Fowke, Peter Pelka, Maya Shmulevitz, Sam K. P. Kung, Darwyn Kobasa, Xiaojian Yao
This study develops a VSV-based multivalent vaccine targeting H5N1 HA and M2e, showing robust neutralizing and ADCC responses and full protection against lethal H5N1 infection in mice.
Journal of Virology · Jun 16, 2026Peer-reviewedMicrobiology