Author

Hideaki Tomita

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Amy Li· 2 shared Libin XuiD· 2 shared Ajaya Ram ShresthaiD· 1 shared David W. BaggettiD· 1 shared Josi M. Herron· 1 shared Kelly Marie HinesiD· 1 shared Takaaki KawanobeiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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2 shared papersNeuroscience

Amy Li

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3 papers

Recent·Most cited

Improved efficacy and tolerability of antisense oligonucleotide with Guanidine- bridged nucleic acid

Takaaki Kawanobe, Ajaya Ram Shrestha, Hideaki Tomita

This study evaluates GuNA-modified ASOs, showing improved KD activity, long-term efficacy, and reduced toxicity in a mouse model.

Nucleic Acid Therapeutics · Oct 29, 2026Peer-reviewedPharmacology & Toxicology

Temporal transcriptomic changes during neurodevelopment in a mouse model of Smith-Lemli-Opitz syndrome

Amy Li, Hideaki Tomita, Libin Xu

This study examines temporal transcriptomic changes in mouse brains with and without SLOS mutations, identifying altered pathways and gene expression patterns at different developmental stages.

The Journal of Steroid Biochemistry and Molecular Biology · Jan 7, 2026Peer-reviewedNeuroscience

7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

Hideaki Tomita, Kelly Marie Hines, Josi M. Herron, Amy Li, David W. Baggett, Libin Xu

This study shows that DHCR7 deficiency leads to oxysterol accumulation, causing premature neurogenesis and neuronal localization issues in SLOS, with GR as a potential therapeutic target.

eLife · Sep 16, 2022Peer-reviewedNeuroscience