David W. Baggett

The paper uses super-resolution microscopy to show that nucleolus granular component sub-phases are organized into multiphase condensates that facilitate ribosome subunit assembly.

The paper develops a machine learning model to predict IDR condensation behavior, finding ~12% of human IDRs likely form condensates, enriched in RNA-related and membrane-less organelle functions.

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.

This study shows that DHCR7 deficiency leads to oxysterol accumulation, causing premature neurogenesis and neuronal localization issues in SLOS, with GR as a potential therapeutic target.