Mycobacterial DNA-binding protein 1 (MDP1) induces RNA condensation as revealed by high-speed AFM
Nadia Shoukat, Akihito Nishiyama, Kaho Nakamoto, Yuna Goto, Phuong Doan N. Nguyen, Hikaru Ichida, Kenichi Umeda, Sohkichi Matsumoto, Noriyuki Kodera
This study shows that MDP1 from Mtb induces RNA condensation through its IDR and PTMs, forming globular structures, while E. coli-expressed MDP1 forms chain-like condensates.
bioRxiv · Aug 3, 2025 · PreprintBiophysics