Involvement of orexin nerves in early stage of Alzheimer's disease model mice and preventive effect of orexin receptor antagonists
Kazuhiro Hada, Yuki Murata, Yoshiaki Ohi, Sana Hashimoto, Hinata Watanabe, Kayoko Ozeki, Takaomi C. Saido, Takashi Saito, Hiroki Sasaguri, Hiroyuki Mizoguchi, Kiyofumi Yamada, Yoshifumi Wakiya
This study investigates the effect of orexin receptor antagonists on early-stage Alzheimer's disease in mice, finding they prevent cognitive impairment and amyloid-beta accumulation.
Journal of Alzheimer s Disease · Mar 1, 2026Peer-reviewedAnimal Behavior & Cognition