Kiyofumi Yamada

This study identifies KCNQ2/3 potassium channels as regulators of synaptic remodeling during withdrawal, showing their activation can suppress cocaine-seeking behavior.

This study compares the effects of fasudil and KD025 on serotonin and dopamine release in the nucleus accumbens of mice, finding distinct roles for Rho-kinase 1 and 2 in neurotransmitter regulation.

This study shows that the selective ROCK2 inhibitor KD025 has antipsychotic-like effects and fewer side effects in schizophrenia models.

This study investigates the effect of orexin receptor antagonists on early-stage Alzheimer's disease in mice, finding they prevent cognitive impairment and amyloid-beta accumulation.

This paper investigates the role of Reelin in schizophrenia by analyzing a mouse model with exonic Reln deletion, finding deficits in excitatory and inhibitory neurons and suggesting therapeutic potential for Reelin replacement.

This study identifies Twinfilin-1 phosphorylation as a key component of reelin signaling that regulates actin dynamics and spine development in neurons.

The paper identifies a phosphorylation pathway initiated by NMDARs that regulates synaptic growth and learning through a cascade involving CaMKII, ARHGEF2, Rho-kinase, and SHANK3.

This study shows that AUTS2 regulates excitatory synapse number to maintain E/I balance, and its loss leads to autistic-like behaviors and increased brain excitability.