Split RNA switch: Programmable and precise control of gene expression by ensemble of pre- and post-translational regulation
Itsuki Abe, Hirohisa Ohno, Megumi Mochizuki, Karin Hayashi, Hirohide Saito
The paper introduces split RNA switches that enhance gene regulation specificity by integrating multiple RNA switches through protein splicing, improving ON/OFF ratios and enabling multi-input synthetic circuits.
bioRxiv · Sep 25, 2024 · PreprintSynthetic Biology