Yeast with elevated chromosome numbers are addicted to high levels of Mps1
Régis E. Meyer, Ashlea Sartin, Madeline Gish, Jillian Harsha, Emily Wilkie, Dawson Haworth, Rebecca LaVictoire, Isabel Alberola, Olivia Bowles, Hoa H. Chuong, Gary J. Gorbsky, Dean Dawson
The paper shows that yeast cells with elevated chromosome numbers are dependent on Mps1 for proper chromosome orientation during mitosis, revealing a mechanism for Mps1 addiction in aneuploid cells.
bioRxiv · Jan 9, 2023 · PreprintGenetics