Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management
Alexandre Moura‐Assis, Kaja Plucińska, Aiste Baleisyte, David Meseguer, Bandy Chen, Kyle Pellegrino, Luca Parolari, Jordan T. Shaked, Keith J. Page, Douglas W. Barrows, Thomas S. Carroll, Jose G. Grajales‐Reyes, Daxiang Na, Hans H. Schiffer, Yun Chen, , Marc Schneeberger
This study identifies a novel target for obesity treatment by showing that inhibiting GABAergic neurons in the dorsal raphe nucleus reduces body weight in diet-induced obese mice through thermogenesis.
bioRxiv · Apr 24, 2025 · PreprintNeuroscience