Thomas S. Carroll

Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation

This study shows that H3K27me3 maintenance in mature neurons via EZH1 has minimal impact on gene expression and chromatin accessibility.

Impaired non-shivering thermogenesis in the desert-dwelling antelope ground squirrel

This study investigates the thermogenic adaptations of antelope ground squirrels by analyzing their genome and transcriptome under cold exposure, revealing a shift toward shivering thermogenesis.

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

This study investigates how the conserved SBD of EZH2 regulates PRC2 activity, showing its necessity for histone methylation and cancer cell proliferation.

Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)

The paper identifies a conserved CSD locus in Ooceraea biroi where heterozygosity triggers female development, showing evolutionary conservation across ant species.

G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

This study identifies G-quadruplexes as a source of genome instability in BRCA2-deficient granule cell progenitors and medulloblastoma, suggesting PIF1 helicase as a therapeutic target.

Acute cold exposure in humans shifts the circulating proteome to a cardioprotective and anti-aging profile

This study identifies a proteomic signature in humans following acute cold exposure that correlates with cardioprotective and anti-aging effects.

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington's disease

This study identifies epigenetic mechanisms linking cell type-specific enhancer activity to somatic CAG expansion and toxicity in Huntington's disease.

Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management

This study identifies a novel target for obesity treatment by showing that inhibiting GABAergic neurons in the dorsal raphe nucleus reduces body weight in diet-induced obese mice through thermogenesis.

ATRX guards against aberrant differentiation in mesenchymal progenitor cells

This study shows that ATRX loss in mesenchymal progenitor cells leads to aberrant differentiation by altering chromatin structure and gene regulation.

Cell Type Specific CAG Repeat Expansions and Toxicity of Mutant Huntingtin in Human Striatum and Cerebellum

The paper investigates CAG repeat expansions and their association with cell death in specific brain regions in Huntington's disease using molecular profiling.

Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington's Disease

The paper identifies layer 5a corticostriatal neurons as selectively vulnerable in Huntington's disease using single nucleus RNA sequencing and shows they have extensive mHTT-CAG expansions.

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

This study shows that H4K91 mutants alter chromatin occupancy and misregulate neuronal differentiation, leading to microcephaly-like phenotypes in mice.

Role of YAP in early ectodermal specification anda Huntington's Disease model of human neurulation

This study investigates YAP's role in early ectodermal specification and its link to Huntington's Disease using human neuruloids, finding YAP activation influences ectodermal fate and that reducing YAP activity can partially rescue HD phenotypes.

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

The paper identifies compartment-specific FMRP targets in CA1 pyramidal neurons and shows how FMRP regulates different mRNA functions in cell bodies and dendrites.

Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

The paper develops a protocol to generate human cerebellar granule cells from pluripotent stem cells and identifies molecular differences in their development compared to mice.

The Taste of Blood in Mosquitoes

The paper identifies specialized stylet neurons in Aedes aegypti mosquitoes that detect blood over nectar, enabling distinct feeding programs for reproduction and survival.

Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics.

This study compares gene expression in human and mouse Purkinje cells using transcriptomics, identifying shared and distinct genetic pathways and a novel human marker gene.