Contaminating manufacturing plasmids and disrupted vector genomes present in liver tissue following adeno-associated virus gene therapy
Sarah Buddle, Li‐An K. Brown, Sofia Morfopoulou, Oscar Enrique Torres Montaguth, Mariacristina Scoto, Vanessa Herder, Anil Kumar Dhawan, Julianne Rose Brown, Laura Atkinson, Angelika Kopec, Dee Davis, Nathaniel Storey, Luis Campos, Neil James Sebire, Hannah L. Macpherson, , Judith Breuer
The paper identifies manufacturing plasmid sequences and disrupted vector genomes in liver tissue from a patient with AAV gene therapy-related hepatitis.
medRxiv · Jan 13, 2025 · PreprintGenetic & Genomic Medicine