Author

Sarah Buddle

University College LondonORCID 0000-0002-4738-9469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:metagenomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Judith BreueriD· 3 shared Julianne Rose BrowniD· 2 shared Laura AtkinsoniD· 2 shared Li‐An K. BrowniD· 2 shared Nathaniel StoreyiD· 2 shared Oscar Enrique Torres MontaguthiD· 2 shared Sofia MorfopoulouiD· 2 shared Angelika Kopec· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Judith BreuerORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintSep 14, 2026

P5 promoter-mediated incorporation explains REP/CAP manufacturing contaminants in patient liver after rAAV gene therapy

Mark A. Brimble, Shaoyuan Tan, Sarah Buddle…·Jeremy Chase Crawford

The paper identifies a mechanism by which REP/CAP contaminants arise in rAAV gene therapy through P5 promoter-mediated incorporation during manufacturing.

DOI 10.64898/2026.09.10.26362787

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintJan 13, 2025

Contaminating manufacturing plasmids and disrupted vector genomes present in liver tissue following adeno-associated virus gene therapy

Sarah Buddle, Li‐An K. Brown, Sofia Morfopoulou…·Judith Breuer

The paper identifies manufacturing plasmid sequences and disrupted vector genomes in liver tissue from a patient with AAV gene therapy-related hepatitis.

DOI 10.1101/2025.01.13.25320105

humanmetagenomics

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Genetic & Genomic MedicineGenome MedicinePeer-reviewedSep 9, 2024

Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

Sarah Buddle, Leysa Forrest, Naomi Akinsuyi…·Oscar Enrique Torres Montaguth

This study compares metagenomics and targeted approaches for virus detection, finding that targeted methods improve sensitivity while untargeted ONT offers better specificity.

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humanmetagenomics

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