Hong Cao

EM3DFold: accurate de novo protein and nucleic acid model building for cryo-EM maps using language model-powered deep learning

EM3DFold improves cryo-EM model building for proteins, nucleic acids, and complexes using a language model-powered deep learning framework, achieving high accuracy on benchmark datasets.

EMAlign: accurate alignment of cryo-EM maps through main-chain probability using deep learning

EMAlign improves cryo-EM map alignment using deep learning to predict main-chain probability, achieving high accuracy and success rates across global and local alignments.

EMReady2: improvement of cryo-EM and cryo-ET maps by local quality-aware deep learning with Mamba

EMReady2 improves cryo-EM and cryo-ET maps using a Mamba-based deep learning model, enhancing quality and interpretability while reducing computational cost.

Accurate protein structure determination from cryo-EM maps using deep learning and structure prediction

EMProt improves protein structure determination from cryo-EM maps using a three-track attention network, outperforming existing methods in accuracy and completeness.

Icariin induces MC3T3-E1 cell proliferation and differentiation via the BMP-2/Smads/Runx2 signal pathway

This study shows icariin promotes MC3T3-E1 cell proliferation and differentiation by activating the BMP-2/Smads/Runx2 pathway.