Tao Li

In Other Words: Learning When to Trust Generated Protein Function Descriptions

The paper introduces a method to assess the reliability of generated protein function descriptions using a judge model and shows it improves performance across multiple methods.

Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation

This study identifies Clec18a as a regulator of innate immune responses by inhibiting inflammation through Trpm7-dependent Cbl activation.

EM3DFold: accurate de novo protein and nucleic acid model building for cryo-EM maps using language model-powered deep learning

EM3DFold improves cryo-EM model building for proteins, nucleic acids, and complexes using a language model-powered deep learning framework, achieving high accuracy on benchmark datasets.

EMAlign: accurate alignment of cryo-EM maps through main-chain probability using deep learning

EMAlign improves cryo-EM map alignment using deep learning to predict main-chain probability, achieving high accuracy and success rates across global and local alignments.

Multi-omics analysis reveals genetic regulatory mechanismsof muscle traits in wild and domesticated Bactrian camels

The paper integrates multi-omics data from Bactrian camels to identify regulatory mechanisms and genetic variants influencing muscle traits.

Comparative genomic analysis reveals reduced pathogenicity of Ralstonia spp. in water

This study compares genomic data from Ralstonia spp. to show reduced pathogenicity in aquatic environments compared to plant and human-associated strains.

Lactate metabolism antagonizes antiviral innate immunity bypromoting VDAC1-lactylation-mediated mtDNA release

This study shows FMDV infection in horse cells increases lactate, which modifies VDAC1 and promotes mtDNA release, activating cGAS-STING and reducing viral replication.