Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia
Naidi Sun, Sun Yu-Yo, Rui Cao, Hong-Ru Chen, Yiming Wang, Elizabeth M. Fugate, Marchelle R. Smucker, Yi-Min Kuo, Patricia Ellen Grant, Diana M. Lindquist, Chia-Yi Kuan, Song Hu
This study uses metabolic analysis to show that hypothermia reverses oxidative phosphorylation uncoupling caused by neonatal brain hypoxia-ischemia, preventing secondary energy failure.
eLife · Dec 29, 2025Peer-reviewedNeuroscience