Song Hu

APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia

This study uses metabolic analysis to show that hypothermia reverses oxidative phosphorylation uncoupling caused by neonatal brain hypoxia-ischemia, preventing secondary energy failure.

Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APPSAA knock-in mouse model of Alzheimer disease

The paper shows that mitochondrial response to nutrients is disrupted early in the cortex of APPSAA mice before symptoms appear, suggesting it as a presymptomatic event in Alzheimer's disease.

SOD1 Mediates Lysosome-to-Mitochondria Communication and its Dysregulation by Amyloid-β Oligomers

The paper identifies SOD1 as a mediator of lysosome-to-mitochondria communication and shows its dysregulation by amyloid-β oligomers in Alzheimer's disease.