This study uses metabolic analysis to show that hypothermia reverses oxidative phosphorylation uncoupling caused by neonatal brain hypoxia-ischemia, preventing secondary energy failure.

eLife · Dec 29, 2025Peer-reviewedNeuroscience

Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype mice

Hong‐Ru Chen, Hsiao‐Tien Chien Hagar, Kuan-Wei Wang, Stacy Hovde, Hsiao‐Yun Lin, Min-Hsuan Lin, Cheng-Chun Chang, Ching-Yung Wang, Chia-Yen Chen, Emily J. Bian, Melissa Marie Kinkaid, Min‐Hao Kuo, Chia-Yi Kuan

The paper investigates the role of hyperphosphorylated tau oligomers in inducing neurodegeneration by injecting them into non-transgenic mice, finding cognitive deficits and neuron death.

bioRxiv · Mar 10, 2025 · PreprintNeuroscience

Microglia modulate cerebral blood flow and neurovascular coupling through ectonucleotidase CD39

Zhongxiao Fu, Mallikarjunarao Ganesana, Philip H. Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu Sun, Emily J. Bian, Aden Weybright, Katia Sol‐Church, Ukpong B. Eyo, Clare Pridans, Francisco Javier Quintana, Simon Christopher Robson, Pankaj Kumar, B. Jill Venton, , Chia-Yi Kuan

This study shows microglia regulate cerebral blood flow through CD39-mediated ATP breakdown, affecting neurovascular coupling and CBF reactivity.

bioRxiv · Nov 5, 2024 · PreprintNeuroscience

Adropin confers neuroprotection and promotes functional recovery from ischemic stroke

Changjun Yang, Bianca P. Lavayen, Lei Liu, Brian D. Sanz, Kelly M. DeMars, Jonathan Larochelle, Marjory Pompilus, Marcelo Febo, Yu Sun, Yi-Min Kuo, Mansour Mohamadzadeh, Susan A. Farr, Chia-Yi Kuan, Andrew A. Butler, Eduardo Candelario‐Jalil

This study shows adropin protects against ischemic stroke by maintaining BBB integrity and reducing neuroinflammation, improving functional recovery in mice.

bioRxiv · Sep 16, 2021 · PreprintNeuroscience

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling

Kanchan Bisht, Kenneth A. Okojie, Kaushik P. Sharma, Dennis H. Lentferink, Yu Sun, Hong‐Ru Chen, Joseph O. Uweru, Saipranusha Amancherla, Zainab Calcuttawala, Antony Brayan Campos-Salazar, Bruce A. Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A. Mills, , Ukpong B. Eyo

The paper identifies capillary-associated microglia (CAMs) and shows they regulate vascular structure and function via PANX1-P2RY12 signaling.

Nature Communications · Sep 6, 2021Peer-reviewedNeuroscience