Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours
Thomas N. Burn, Jan Schröder, Luke C. Gandolfo, Maleika Osman, Elanor N. Wainwright, Enid Y.N. Lam, Keely M. McDonald, Rachel B. Evans, Shihan Li, Daniel Rawlinson, Lachlan Dryburgh, Ali Zaid, Zoltan Maliga, Dominick Schienstock, Philippa Meiser, , Laura K. Mackay
This study distinguishes tissue-resident memory (TRM) and exhausted T (TEX) cells in tumors by analyzing their antigen reactivity, clonality, and functional outcomes.
bioRxiv · Jul 23, 2025 · PreprintImmunology