Jan Schröder

This study investigates how a maternal low protein diet affects kidney development in mice, revealing molecular and cellular changes that reduce nephron number.

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

This study distinguishes tissue-resident memory (TRM) and exhausted T (TEX) cells in tumors by analyzing their antigen reactivity, clonality, and functional outcomes.

Damsel provides an R package for end-to-end analysis of DamID sequencing data, including quantification, testing, and visualization of protein-DNA interactions.

The paper identifies how JNK and Hippo pathways regulate epithelial integrity by controlling an overlapping transcriptome, preventing tumour initiation through shared gene repression.

The paper analyzes the transcriptomic response of microglia in an Alzheimer's disease mouse model treated with scanning ultrasound, identifying differentially expressed genes and pathways related to phagocytosis and cell cycle activation.

This study identifies Nr6a1 as a master regulator of trunk-specific axial development in mice, controlling elongation, segmentation, and lineage allocation through Hox gene regulation and gene regulatory networks.

This study examines how T cell activation alters chromatin structure and gene expression, identifying changes in chromatin interactions and domain organization.

This study benchmarks error-correction methods for next-generation sequencing data, finding significant variation in performance across datasets with no single method being optimal overall.

GRIDSS detects genomic rearrangements with high sensitivity and specificity using a positional de Bruijn graph assembler, outperforming existing methods on simulated and tumor data.