A Novel FNDC1-NAMPT-NAD axis is Implicated in Small and Large-vessel Arterial Disease and Drives Vascular Calcification
Sujin Lee, Yugene Y. Guo, Lova Prasadareddy Kajuluri, Kangsan Roh, Kuldeep Singh, Wanlin Jiang, Elizabeth Moore, Helena Tattersfield, Katrina F. Ostrom, Claire Birchenough, Adam L. Johnson, Scott Krinsky, Houda Bouchouari, Mohammed Mohammedeh, Laurel Yong-Hwa Lee, , Rajeev Kumar Malhotra
This study identifies FNDC1 as a key regulator of vascular calcification through the FNDC1-NAMPT-NAD axis, showing its role in both microvascular and macrovascular diseases and its potential as a therapeutic target.
bioRxiv · Jul 8, 2025 · PreprintCell Biology