Palmitoylation of p75 neurotrophin receptor is required for retrograde regressive signaling
Amrita Pathak, Hrishita Das, Pooja Shukla, Austin B. Keeler, Christopher D. Deppmann, Bruce Douglas Carter
This study shows that palmitoylation of p75NTR at C281 is essential for retrograde signaling by enabling the formation of p75ICD-positive endosomes for axonal transport and apoptosis.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience