Austin B. Keeler

Palmitoylation of p75 neurotrophin receptor is required for retrograde regressive signaling

This study shows that palmitoylation of p75NTR at C281 is essential for retrograde signaling by enabling the formation of p75ICD-positive endosomes for axonal transport and apoptosis.

Characterizing microglial signaling dynamics during inflammation using single-cell mass cytometry

This study uses single-cell mass cytometry to analyze microglial signaling dynamics during inflammation, revealing distinct responses to LPS and Poly(I:C) and the modulating effect of astrocytes.

A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs

This paper shows small-molecule GLP1RAs modulate reward processing via a specific neural circuit in the central amygdala, affecting dopamine release and hedonic feeding.

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

The paper identifies TrkA as a cargo in sympathetic neuron-derived extracellular vesicles and shows it is retrogradely transported and secreted.

A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry

This study uses single-cell mass cytometry to map somatosensory development in mouse dorsal root ganglia, identifying distinct cell states and highlighting differences between protein and mRNA expression.

A developmental atlas of the mouse brain by single-cell mass cytometry

The paper constructs a developmental atlas of the mouse brain using single-cell mass cytometry, identifying 85 molecularly distinct cell populations and revealing discrepancies between protein and mRNA abundances.