Structural insights into sphingosine 1-phosphate receptor 4 activation
Wei Gao, Shiyi Gan, Mengting Zhang, Asuka Inoue, Mengting Xie, Huan He, Huan Zhu, Shanshan Guo, Chen Qiu, Di Chang, Jinling Yu, Zhuo Deng, Fang Ye, Shiliang Li, Jian Zhang, , Honglin Li
The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.
bioRxiv · Mar 2, 2024 · PreprintBiochemistry