Fang Ye

This paper introduces a benchmark to evaluate single-cell drug perturbation models by assessing their fidelity to drug-response signatures, finding that expression similarity is a poor proxy for mechanism preservation.

This study uses single-nuclear RNA sequencing to show that ATF3 is not required for postoperative pain, and identifies c-Jun as a potential ATF3-independent driver of the injury program.

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.