Author

Honglin Li

East China University of Science and TechnologyORCID 0000-0002-6773-4207Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Honglin Li1 paper · Heilongjiang University of Chinese Medicine

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Lili Zhu· 3 shared Jiawen Wang· 2 shared Mengzhu Xue· 2 shared Shanshan Ruan· 2 shared Shiliang LiiD· 2 shared Tianyu Ye· 2 shared Asuka InoueiD· 1 shared Bernard OfosuheneiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiochemistry

Lili Zhu

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Author profile →

3 papers

Recent·Most cited

Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure

Mengzhu Xue, Yingquan Liang, Zhen Yuan, Xiangning Liu, Longfeng Chang, Yongzhi Wang, Peijia Xu, Tingting Zhang, Hewei Jiang, Zijie Zhao, Jingqiu Liu, Shanshan Ruan, Tianyu Ye, Xuelian Pang, 梅文一, , Honglin Li

This study identifies a compound that inhibits RhoA activation by stabilizing its GDP state, reducing myocardial remodeling and fibrosis in heart failure models.

Circulation Research · Mar 20, 2026Peer-reviewedPharmacology & Toxicology

TRPV4 Inhibition by a Natural Product Mediates Analgesia

Zhen Yuan, Jie Qiu, Shiliang Li, Hanqing Zhao, Na Chen, Shanshan Ruan, Yu Gan, Jiawen Wang, Tianyu Ye, Wenjie Liao, Ziyuan Li, Yanyan Diao, Lili Zhu, Zhenjiang Zhao, Rui Wang, , Bowen Ke

This study identifies AH001 as a potent TRPV4 inhibitor, revealing its mechanism and demonstrating its analgesic effects in pain models.

bioRxiv · Jan 5, 2026 · PreprintBiochemistry

Structural insights into sphingosine 1-phosphate receptor 4 activation

Wei Gao, Shiyi Gan, Mengting Zhang, Asuka Inoue, Mengting Xie, Huan He, Huan Zhu, Shanshan Guo, Chen Qiu, Di Chang, Jinling Yu, Zhuo Deng, Fang Ye, Shiliang Li, Jian Zhang, , Honglin Li

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

bioRxiv · Mar 2, 2024 · PreprintBiochemistry