Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika Neuropathogenesis
Md Musaddaqul Hasib, Wen Meng, Gonzalo E. Mena, Hugh Halloway, Suzane Ramos da Silva, Gary Kohanbash, Yufei Huang, Shou‐Jiang Gao
This study uses spatial transcriptomics to compare how Asian and African Zika strains affect microglial states and brain tissue organization in mice, revealing strain-specific mechanisms of neuropathogenesis.
bioRxiv · May 5, 2026 · PreprintCell Biology