Gary Kohanbash

Complementary cytotoxicity of GD2-targeted photoimmunotherapy and 5-aminolevulinic acid photodynamic therapy in neuroblastoma and osteosarcoma

This study combines GD2-targeted photoimmunotherapy and 5-aminolevulinic acid photodynamic therapy to enhance cytotoxicity and reduce light-dose requirements in neuroblastoma and osteosarcoma.

Development and Optimization of 111In-Dinutuximab-IRDye800, a Dual-Modality Intraoperative Molecular Imaging Agent for Pediatric Neuroblastoma Resection

This paper develops and optimizes 111In-Dinutuximab-IRDye800, a dual-modality imaging agent for neuroblastoma resection, finding that an optimal dose and ratio maximize tumor detection.

MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression

This study shows that inhibiting MALT1 protease in glioblastoma-associated macrophages reduces immunosuppression and tumor growth by reprogramming macrophages to an M1-like phenotype.

Spatially Resolved Microglial State Transitions Govern Strain-Specific Zika Neuropathogenesis

This study uses spatial transcriptomics to compare how Asian and African Zika strains affect microglial states and brain tissue organization in mice, revealing strain-specific mechanisms of neuropathogenesis.

CD200 depletion in glioma enhances antitumor immunity and induces tumor rejection

This study shows that CD200 depletion in gliomas enhances antitumor immunity and leads to tumor rejection by modulating immune cell activity and cytokine expression.