Gonzalo E. Mena

Factorizing multiple monotone pseudotimes into one shared donor permutation plus cluster-specific warps (HiP-BIND) yields Alzheimer's donor orderings agreeing better with Braak, ADNC and CERAD staging than single-trajectory B-BIND.

This study uses spatial transcriptomics to compare how Asian and African Zika strains affect microglial states and brain tissue organization in mice, revealing strain-specific mechanisms of neuropathogenesis.

This paper introduces a Bayesian framework to infer continuous disease states from discrete pathological protein measurements in Alzheimer's Disease, using pseudotime to model progression.

The paper maps AD-related pathological changes in the caudate nucleus at cellular resolution, identifying distinct features and cell type-specific responses.

This study creates an integrated multimodal cell atlas of Alzheimer's disease by analyzing single nuclei transcriptomes, epigenomes, and spatial coordinates across AD stages.

The paper introduces NeuroPAL, a multicolor transgene for neuronal identification in C. elegans, and demonstrates its use in mapping neurotransmitter receptors, cell fate changes, and brain activity.

The paper develops a Gaussian Process model to cancel electrical stimulation artifacts and detect neural spikes in multi-electrode recordings, achieving low error rates and real-time compatibility.