NMNAT2 in cortical glutamatergic neurons exerts both cell and non-cell autonomous influences to shape cortical development and to maintain neuronal health
Zhen‐Xian Niou, Sen Yang, Anoosha Sri, Hugo Rodriquez, Jonathan Gilley, Michael P. Coleman, Hui‐Chen Lu
This study shows that NMNAT2 deletion in cortical glutamatergic neurons causes neurodegeneration and disrupts cortical development, with Sarm1 loss partially rescuing these effects.
bioRxiv · Feb 5, 2022 · PreprintNeuroscience