Author

Zhen‐Xian Niou

Indiana University BloomingtonORCID 0000-0002-4683-1964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hui‐Chen LuiD· 3 shared Sen YangiD· 3 shared Andrea EnriqueziD· 2 shared Anoosha Sri· 2 shared Jason M. TennesseniD· 2 shared Jonathan GilleyiD· 2 shared Jui-Yen HuangiD· 2 shared Michael P. ColemaniD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Hui‐Chen LuORCID

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3 papers

Recent·Most cited

NAD+ reduction in glutamatergic neurons triggers fatty acid catabolism and neuroinflammation in the brain, mitigated by SARM1 deletion

Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui-Yen Huang, Hui‐Chen Lu

The paper shows that loss of NMNAT2 in glutamatergic neurons causes metabolic shifts and neurodegeneration, which are mitigated by SARM1 deletion.

bioRxiv · May 5, 2025 · PreprintNeuroscience

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in mice

Sen Yang, Zhen‐Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar‐Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui‐Chen Lu

This study shows NMNAT2 maintains NAD redox potential in axons to support glycolysis and fast transport, preventing axonal degeneration in mice.

bioRxiv · Feb 6, 2022 · PreprintNeuroscience

NMNAT2 in cortical glutamatergic neurons exerts both cell and non-cell autonomous influences to shape cortical development and to maintain neuronal health

Zhen‐Xian Niou, Sen Yang, Anoosha Sri, Hugo Rodriquez, Jonathan Gilley, Michael P. Coleman, Hui‐Chen Lu

This study shows that NMNAT2 deletion in cortical glutamatergic neurons causes neurodegeneration and disrupts cortical development, with Sarm1 loss partially rescuing these effects.

bioRxiv · Feb 5, 2022 · PreprintNeuroscience