Microbial neurosteroid biosynthesis: Holdemania filiformis generates isopregnanolone that reaches the brain via gut-to-brain transport
Guo-Jie Brandon-Mong, Chia‐Hung Chou, Tien-Yu Wu, Ronnie Gicaraya Gicana, Chien-Tao Huang, Guan-Lun Wu, Ya-Che Li, Yan-Li Tu, Yu-Yuan Chang, Yi-Li Lai, Po-Ting Li, Hui-Yu Chen, Tsun‐Hsien Hsiao, Mei‐Jou Chen, Yin‐Ru Chiang
This study identifies Holdemania filiformis as a gut microbe producing isopregnanolone, which reaches the brain via the gut-brain axis, suggesting its potential as a probiotic for mood disorders.
bioRxiv · Dec 12, 2024 · PreprintMicrobiology