Yin‐Ru Chiang

Multigram-scale stereoselective synthesis of neurosteroid isomers by gut microbial isolates using plant biomass-derived medium

This paper identifies gut bacteria that stereoselectively synthesize neurosteroid isomers using a plant-based medium, achieving high conversion and purity without chiral purification.

Multi-omics integration uncovers host-microbiota crosstalk underlying sexual differentiation in the shortfin eel Anguilla bicolor pacifica

This study integrates multi-omics data to show gut microbiota composition and function are linked to sexual differentiation in shortfin eels.

Aromatase-independent estrogenesis: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere

This paper discovers aromatase-independent estrogenesis in an anaerobic bacterium, suggesting the Wood-Ljungdahl pathway may have contributed to the emergence of estrogens in the biosphere.

Microbial neurosteroid biosynthesis: Holdemania filiformis generates isopregnanolone that reaches the brain via gut-to-brain transport

This study identifies Holdemania filiformis as a gut microbe producing isopregnanolone, which reaches the brain via the gut-brain axis, suggesting its potential as a probiotic for mood disorders.

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.