Tien-Yu Wu

This paper identifies gut bacteria that stereoselectively synthesize neurosteroid isomers using a plant-based medium, achieving high conversion and purity without chiral purification.

This paper discovers aromatase-independent estrogenesis in an anaerobic bacterium, suggesting the Wood-Ljungdahl pathway may have contributed to the emergence of estrogens in the biosphere.

This study identifies Holdemania filiformis as a gut microbe producing isopregnanolone, which reaches the brain via the gut-brain axis, suggesting its potential as a probiotic for mood disorders.

This study identifies Clostridium innocuum as a gut bacterium that inactivates progesterone by converting it to epipregnanolone, leading to decreased serum progesterone and follicular arrest in mice.