Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition
Cameron T. Flower, C. Liu, Hui-Yu Chuang, Xiaoyang Ye, Hanjun Cheng, James R. Heath, Wei Wei, Forest M. White
The paper investigates early signaling and transcriptional changes in melanoma cells under BRAF inhibitor treatment, identifying SFK activation as a compensatory mechanism and demonstrating its sensitivity to co-inhibition.
Cell Systems · Apr 1, 2025Peer-reviewedSystems Biology