Wei Wei

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small cell lung cancer

This study uses spatial multi-omics to show cSCLC has a monoclonal origin, lineage plasticity, and distinct microenvironment niches, leading to a new diagnostic assay.

DTCFinder: a bench-to-bits toolkit for label-free, whole-spectrum analysis of disseminated and circulating tumor cells in liquid biopsies

DTCFinder detects and characterizes disseminated and circulating tumor cells in liquid biopsies using single-cell RNA sequencing and machine learning without relying on labels or markers.

Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition

The paper investigates early signaling and transcriptional changes in melanoma cells under BRAF inhibitor treatment, identifying SFK activation as a compensatory mechanism and demonstrating its sensitivity to co-inhibition.

Applicability of Castration Model in Sex Difference Studies: Insights from Metabolome and Transcriptome Analyses

This study evaluates the castration model's utility in sex difference research using metabolome and transcriptome analyses in mice, showing it can feminize metabolic and transcriptomic profiles.