Cameron T. Flower

Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT

The paper introduces INSIGHT, a platform for phosphoproteomic analysis of rare cell subpopulations, and applies it to study signaling changes in disseminated glioblastoma cells in vivo.

Tyrosine phosphoproteome profiling identifies cell-intrinsic signals limiting the efficacy of tyrosine kinase inhibitor therapies

This study identifies cell-intrinsic phosphotyrosine signaling patterns that limit tyrosine kinase inhibitor efficacy in cancer cell lines.

Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition

The paper investigates early signaling and transcriptional changes in melanoma cells under BRAF inhibitor treatment, identifying SFK activation as a compensatory mechanism and demonstrating its sensitivity to co-inhibition.

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

This study identifies sex-specific metabolic reprogramming in obesity by analyzing phosphorylation sites on metabolic enzymes and their functional impact.