Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection
Huan Zhang, Yuanzhi Wang, Yueli Wang, Huilin Hou, Yaqian Wang, Xiaoyu Deng, Zhenyu Xu, Xujin Xia, Mingguo Xu, Zhen Wang, Yong Wang, Changsuo Zhang, Zhumanov Kairat Toksanbaevich, Jinliang Sheng, Hui Zhang, , Chuangfu Chen
This study identifies Brucella PrpA as a protein that activates the Tpl2-ERK pathway to induce IL-10 secretion in macrophages, promoting chronic infection and suggesting the prpA mutant as a potential vaccine.
Frontiers in Immunology · Jun 9, 2026Peer-reviewedMicrobiology