MicrobiologyFrontiers in ImmunologyPeer-reviewed
Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection
Huan Zhang, Yuanzhi Wang, Yueli Wang…·Chuangfu Chen
This study identifies Brucella PrpA as a protein that activates the Tpl2-ERK pathway to induce IL-10 secretion in macrophages, promoting chronic infection and suggesting the prpA mutant as a potential vaccine.
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