Modelling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype
Stephen Qi Rong Wong, Mohua Das, Kenzom Tenzin, Niranjan Shirgaonkar, Huiwen Chua, Lin Xuan Chee, Ahpa Sae Yeoh, Astley Aruna Murugiah, Wei Yong Chua, Madelaine Skolastika Theardy, Ethan Jadon Subel, Matan Thangavelu Thangavelu, Jane Vin Chan, Choon Kong Yap, Iain Bee Huat Tan, , Ramanuj DasGupta
This paper identifies a SERPINE1-based gene signature (RESIST-M) that predicts oxaliplatin resistance and metastasis in colorectal cancer and proposes therapeutic strategies targeting this pathway.
Cell Death and Disease · Jul 16, 2025Peer-reviewedCancer Biology