Author

Madelaine Skolastika Theardy

Agency for Science, Technology and ResearchORCID 0000-0003-2560-775XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ahpa Sae Yeoh· 1 shared Alec A. SchmaieriD· 1 shared Alexey V. SorokiniD· 1 shared Alexis CaulieriD· 1 shared Andrew LeeiD· 1 shared Angela K. DeemiD· 1 shared Anirban MaitraiD· 1 shared Astley Aruna Murugiah· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

Ahpa Sae Yeoh

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 8, 2026

Durable and reversible epigenetic programming of human hematopoietic stem cells as a platform for modulation of platelet function

Tianyi Ye, Wanying Xu, María N. Barrachina…·Vijay G. Sankaran

This study uses DNA methylation-based epigenome editing to durably and reversibly silence genes in human hematopoietic stem cells, demonstrating its application in modulating platelet function.

DOI 10.64898/2026.03.27.714536

humanDNA methylation

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Cancer BiologyCell Reports MedicinePeer-reviewedJul 25, 2025

Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

Madelaine Skolastika Theardy, Mitsunobu Takeda, Alexey V. Sorokin…·Wantong Yao

This study identifies the YAP1-SDC1 axis as a driver of resistance to mKRAS inhibitors in gastrointestinal cancers and suggests targeting this axis to overcome resistance.

6 citations

humanexperimental assay

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Cancer BiologyCell Death and DiseasePeer-reviewedJul 16, 2025

Modelling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype

Stephen Qi Rong Wong, Mohua Das, Kenzom Tenzin…·Ramanuj DasGupta

This paper identifies a SERPINE1-based gene signature (RESIST-M) that predicts oxaliplatin resistance and metastasis in colorectal cancer and proposes therapeutic strategies targeting this pathway.

16 citationstop 3%

humanbulk RNA-seq

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