Ramanuj DasGupta

The paper introduces a microfluidic device with machine learning analysis to study immune-epithelial interactions during airway infection, revealing distinct immune cell behaviors under RSV infection and therapeutic intervention.

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

This study identifies Cyclin L1 as a host factor that regulates Hepatitis B Virus replication by modulating RNA Polymerase II phosphorylation and activity.

This study integrates chromatin accessibility and transcriptomics data from ovarian tumor-infiltrating adaptive NK cells to identify key transcription factors and their regulatory networks.

This paper identifies a SERPINE1-based gene signature (RESIST-M) that predicts oxaliplatin resistance and metastasis in colorectal cancer and proposes therapeutic strategies targeting this pathway.

This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.

This study benchmarks Nanopore long read RNA sequencing in human cell lines, showing improved isoform resolution compared to short reads.

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

This study develops a single-nucleus CUT&RUN assay to analyze histone modifications in HNSCC cell lines, revealing how epigenetic changes contribute to cancer progression and heterogeneity.

The paper profiles single-cell transcriptomes of CHB and FC patients to identify immune cell states associated with functional cure.

The paper uses single-cell RNA-seq data to predict drug responses and combinations by analyzing intra-tumor transcriptomic heterogeneity in cancer cell lines.

The paper uses scRNA-seq to identify TROP2+ liver progenitor cells co-expressing ACE2 and TMPRSS2, suggesting they may be targets for SARS-CoV-2 infection and contribute to COVID-19-associated liver dysfunction.

The paper identifies and functionally characterizes tRNA-derived small RNAs (tsRNAs) in cell state transitions, showing their role in regulating translation and stem cell states.