High Consumption of Coffee Disrupts Nonhomologous End Joining Implications for Genomic Stability
Susmita Kumari, Humaira Siddiqua, Sathees C. Raghavan
This study shows that coffee decoction inhibits nonhomologous end joining (NHEJ) by targeting the Ligase IV/XRCC4 complex, leading to DNA damage accumulation and implications for cancer therapy.
bioRxiv · Apr 7, 2026 · PreprintBiochemistry