Sathees C. Raghavan

Endosulfan rewires GSK3β to disrupt primary cilia-dependent Hedgehog signalling

This study shows endosulfan disrupts Hedgehog signaling by altering GSK3β activity, leading to ciliopathy-like effects in mice and linking to human reproductive disorders.

Conformational activation of GSK3β by an environmental toxicant suppresses hedgehog signalling

This study shows endosulfan, a pesticide, suppresses hedgehog signaling by activating GSK3β and repressing GLI-regulated genes, mimicking genetic ciliopathies.

High Consumption of Coffee Disrupts Nonhomologous End Joining Implications for Genomic Stability

This study shows that coffee decoction inhibits nonhomologous end joining (NHEJ) by targeting the Ligase IV/XRCC4 complex, leading to DNA damage accumulation and implications for cancer therapy.

Mitochondrial G4 DNA Cleavage by EndoG Activates a Flexible, Stress-Dependent Repair Response via Double strand break repair pathways

The paper identifies a stress-dependent mitochondrial DNA repair mechanism involving EndoG-induced double-strand breaks resolved by MMEJ and HR.

Unleashing a Novel Function of Endonuclease G in Mitochondrial Genome Instability

This study identifies a novel function of Endonuclease G in inducing mitochondrial DNA deletions through G-quadruplex binding and microhomology-mediated repair.