Parkinsons Disease Pathology is Directly Correlated to SIRT3 in Human Subjects and Animal Models: Implications for AAV.SIRT3-myc as a Disease-Modifying Therapy.
Dennison Trinh, Ahmad R. Israwi, Harsimar Brar, Jose E.A. Villafuerte, Ruella Laylo, Humaiyra Patel, Sabika Jafri, Lina Al Halabi, Shaumia Sinnathurai, Kiran Reehal, Alyssa Shi, Vayisnavei Gnanamanogaran, Natalie Garabedian, Ivy Pham, Drake R. Thrasher, , Joanne E. Nash
This paper shows SIRT3 levels decrease with age and in Parkinson's disease, and over-expression of SIRT3 reduces α-synuclein aggregation, supporting AAV.SIRT3-myc as a potential therapy.
Neurobiology of Disease · Sep 11, 2023Peer-reviewedNeuroscience