Tetracycline-Regulated Inducible CB2 Expression in AtT20 Cells: A Functional Assay for Quantifying Ligand Efficacy
Tahira Foyzun, Mark A. Connor, Humayra Zaman, Michael Kassiou, Annukka Kallinen, Marina Santiago
This paper establishes an inducible CB2 expression system in AtT20 cells to quantify ligand efficacy using the operational model, finding that AK-F-064, CP55940, and 2-AG have higher efficacy than AEA.
bioRxiv · Mar 2, 2026 · PreprintPharmacology & Toxicology